2,389 research outputs found
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Understanding analogical reasoning : viewpoints from psychology and related disciplines
Analogy and metaphor have a long history of study in linguistics, education, philosophy and psychology. Consensus over what analogy is or how analogy functions in language and thought, however, has been elusive. This paper, the first in a two part series, examines these various research traditions, attempting to bring out major lines of agreement over the role of analogy in individual human experience. As well as being a general literature review which may be helpful for newcomers to the study of analogy, this paper attempts to extract from these literatures existing theories, models and concepts which may be interesting or useful for computational studies of analogical reasoning
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Understanding analogical reasoning : computational approaches
Analogical reasoning has a seductive history in artificial intelligence (AI) because of its assumed promise for the acquisition and effective use of knowledge. This paper, the second of a two part series, reviews a vartiety of efforts at capturing some of this promise in the existig AI literature. Studies are reviewed chronologically within broadly defined task domains, and a simple framework for examining components of analogical reasoning is developed for comparing computational studies. This framework, and many of the ideas surrounding it, are related to important but often overlooked contributions from other academic disciplines reviewed in the first paper of this series. Particular emphasis is given here to the role of analogical reasoning in machine learning
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Toward a taxonomy of methodological perspectives in artificial intelligence research
This paper is an attempt to explain apparent confusion of efforts in the field of artificial intelligence (AI) research in terms of differences between underlying methodological perspectives held by practicing researchers. A review of such perspectives discussed in the existing literature will be presented, followed by consideration of what a relatively specific and usable taxonomy of differing research perspectives in AI might include. An argument will be developed that researchers should make their methodological orientations explicit when communicating research results, both as an aid to comprehensibility for other practicing researchers and as a step towards providing a coherent intellectual structure which can be more easily assimilated by newcomers to the field
Measurement of gut permeability using fluorescent tracer agent technology
Abstract The healthy gut restricts macromolecular and bacterial movement across tight junctions, while increased intestinal permeability accompanies many intestinal disorders. Dual sugar absorption tests, which measure intestinal permeability in humans, present challenges. Therefore, we asked if enterally administered fluorescent tracers could ascertain mucosal integrity, because transcutaneous measurement of differentially absorbed molecules could enable specimen-free evaluation of permeability. We induced small bowel injury in rats using high- (15āmg/kg), intermediate- (10āmg/kg), and low- (5āmg/kg) dose indomethacin. Then, we compared urinary ratios of enterally administered fluorescent tracers MB-402 and MB-301 to urinary ratios of sugar tracers lactulose and rhamnose. We also tested the ability of transcutaneous sensors to measure the ratios of absorbed fluorophores. Urinary fluorophore and sugar ratios reflect gut injury in an indomethacin dose dependent manner. The fluorophores generated smooth curvilinear ratio trajectories with wide dynamic ranges. The more chaotic sugar ratios had narrower dynamic ranges. Fluorophore ratios measured through the skin distinguished indomethacin-challenged from same day control rats. Enterally administered fluorophores can identify intestinal injury in a rat model. Fluorophore ratios are measureable through the skin, obviating drawbacks of dual sugar absorption tests. Pending validation, this technology should be considered for human use
The natural history of respiratory syncytial virus in a birth cohort : the influence of age and previous infection on reinfection and disease
This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was monitored for respiratory syncytial virus infections from January 31, 2002, to April 22, 2005. Predictors of infection were examined by Cox regression and disease risk by binomial regression. A total of 598 respiratory syncytial virus infections were identified (411 primary, 187 repeat), with 409 determined by antigen assay and 189 by antibody alone (using a āmost pragmaticā serologic definition). The incidence decreased by 70% following a primary infection (adjusted hazard ratio = 0.30, 95% confidence interval: 0.21, 0.42; P < 0.001) and by 59% following a secondary infection (hazard ratio = 0.41, 95% confidence interval: 0.22, 0.73; P = 0.003), for a period lasting 6 months. Relative to the age group <6 months, all ages exhibited a higher incidence of infection. A lower risk of severe disease following infection was independently associated with increasing age (P < 0.001) but not reinfection. In conclusion, observed respiratory syncytial virus incidence was lowest in the first 6 months of life, immunity to reinfection was partial and short lived, and disease risk was age related
Dynamic phase diagram of the REM
By studying the two-time overlap correlation function, we give a
comprehensive analysis of the phase diagram of the Random Hopping Dynamics of
the Random Energy Model (REM) on time-scales that are exponential in the
volume. These results are derived from the convergence properties of the clock
process associated to the dynamics and fine properties of the simple random
walk in the -dimensional discrete cube.Comment: This paper is in large part based on the unpublished work
arXiv:1008.3849. In particular, the analysis of the overlap correlation
function is new as well as the study of the high temperature and short
time-scale transition line between aging and stationarit
The negatively charged nitrogen-vacancy centre in diamond: the electronic solution
The negatively charged nitrogen-vacancy centre is a unique defect in diamond
that possesses properties highly suited to many applications, including quantum
information processing, quantum metrology, and biolabelling. Although the
unique properties of the centre have been extensively documented and utilised,
a detailed understanding of the physics of the centre has not yet been
achieved. Indeed there persists a number of points of contention regarding the
electronic structure of the centre, such as the ordering of the dark
intermediate singlet states. Without a sound model of the centre's electronic
structure, the understanding of the system's unique dynamical properties can
not effectively progress. In this work, the molecular model of the defect
centre is fully developed to provide a self consistent model of the complete
electronic structure of the centre. The application of the model to describe
the effects of electric, magnetic and strain interactions, as well as the
variation of the centre's fine structure with temperature, provides an
invaluable tool to those studying the centre and a means to design future
empirical and ab initio studies of this important defect.Comment: 24 pages, 6 figures, 10 table
Depth resolved snapshot energy-dispersive X-ray diffraction using a conical shell beam
We demonstrate a novel imaging architecture to collect range encoded diffraction patterns from overlapping samples in a single conical shell projection. The patterns were measured in the dark area encompassed by the beam via a centrally positioned aperture optically coupled to a pixelated energy-resolving detector. We show that a single exposure measurement of 0.3 mAs enables d-spacing values to be calculated. The axial positions of the samples were not required and the resultant measurements were robust in the presence of crystallographic textures. Our results demonstrate rapid volumetric materials characterization and the potential for a direct imaging method, which is of great relevance to applications in medicine, non-destructive testing and security screening
The CMS Tracker Readout Front End Driver
The Front End Driver, FED, is a 9U 400mm VME64x card designed for reading out
the Compact Muon Solenoid, CMS, silicon tracker signals transmitted by the
APV25 analogue pipeline Application Specific Integrated Circuits. The FED
receives the signals via 96 optical fibers at a total input rate of 3.4 GB/sec.
The signals are digitized and processed by applying algorithms for pedestal and
common mode noise subtraction. Algorithms that search for clusters of hits are
used to further reduce the input rate. Only the cluster data along with trigger
information of the event are transmitted to the CMS data acquisition system
using the S-LINK64 protocol at a maximum rate of 400 MB/sec. All data
processing algorithms on the FED are executed in large on-board Field
Programmable Gate Arrays. Results on the design, performance, testing and
quality control of the FED are presented and discussed
The Performance of Private Equity Funds: Does Diversification Matter?
This paper is the first systematic analysis of the impact of diversification on the performance of private equity funds. A unique data set allows the exact evaluation of diversification across the dimensions financing stages, industries, and countries. Very different levels of diversification can be observed across sample funds. While some funds are highly specialized others are highly diversified. The empirical results show that the rate of return of private equity funds declines with diversification across financing stages, but increases with diversification across industries. Accordingly, the fraction of portfolio companies which have a negative return or return nothing at all, increase with diversification across financing stages. Diversification across countries has no systematic effect on the performance of private equity funds
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